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Case of the Week 549



What is the most likely diagnosis?

  • 28 year-old with history of recurrent pulmonary infections and diabetes



Frontal Radiograph of Chest

  1. Metastatic Osteosarcoma
  2. Kartagener Syndrome
  3. Eosinophilic Granuloma
  4. Scleroderma
  5. Cystic Fibrosis

Additional Images - None

 

Additional Images

 


None


Answer:

 

5. Cystic Fibrosis

 

More (Click Discussion Tab)

 

 

Cystic Fibrosis

General considerations

  • Disease of abnormal exocrine gland function
  • Autosomal recessive almost always in Caucasians
    • Defect in gene which codes for cystic fibrosis transmembrane conductance regulator (CFTR)
  • Major clinical manifestations are pulmonary and pancreatic insufficiency
  • Elevated concentration of sodium and chloride in sweat
  • Most patients are diagnosed by age 1year

MORE . . .

 


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is an award-winning educational website aimed primarily at medical students and radiology residents-in-training, containing  lectures, handouts, images, Cases of the Week, archives of cases, quizzes, flashcards of differential diagnoses and “most commons” lists, primarily in the areas of chest, GI, GU cardiac, bone and neuroradiology.