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Case of the Week 534


What is the most likely diagnosis?

  • 71 year-old with dysphagia



Frontal Radiograph of the Chest

  1. Overdistension of ETT Balloon
  2. Aspiration Pneumonia
  3. Tracheomegaly
  4. Pneumomediastinum
  5. Achalasia

Additional Image-Esophagram

 

Additional Images

 


Esophagram


Answer:

 

5. Achalasia

 

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Achalasia

General Considerations

  • Usually idiopathic in origin
    • Degeneration of neurons within the myenteric plexus of the esophageal smooth muscle
  • Neuronal destruction is typically inflammatory in nature
    • Histologically: lymphocytic infiltrate surrounding the plexus
    • Predominantly involves the nitric-oxide producing inhibitory neurons
      • Cause smooth muscle relaxation by inhibiting the acetylcholine producing excitatory neurons
  • Loss of inhibitory input results in unopposed contractile stimulation and aperistalsis
    • Acetylcholine producing neurons (which stimulate smooth muscle contraction) are relatively spared in this degenerative process

MORE . . .

 


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