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Case of the Week 412 
What is the most likely diagnosis?
- 28 year-old male with epistaxis
Contrast-enhanced axial CT scans through liver
- Splenic cyst
- Gastric outlet obstruction
- Osler-Weber-Rendu Disease
- Hepatocellular carcinoma
- Adrenal adenoma
Additional Images - None
Additional Images
None
Answer:
.
3. Osler-Weber-Rendu Disease
.
.
More (Click Discussion Tab)
Osler-Weber-Rendu Disease
- Also known as hereditary hemorrhagic telangiectasia (HHT) and Rendu-Osler-Weber syndrome
- It is a disease characterized by mucosal and cutaneous telangiectasias and arteriovenous malformations (AVMs)
- Oddly enough, Osler-Weber-Rendu Disease (OWRD) was first described by Sutton in 1864 but, alas, Sutton’s name is not on the disease
- The disease is named after Henri Rendu (1896), Sir William Osler (1901) and Frederick Parks Weber (1907) who described various aspects of the syndrome in the years cited
- Pronounced OHz-ler, ren-DYU, and VAY-ber (Germanic pronunciation of his name)
- It is autosomal dominant with variable penetrance
- Most frequent cause maps to the long arm of chromosome 9
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The top diagnostic imaging diagnoses that all medical students should recognize according to the Alliance of Medical Student Educators in Radiology |
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is an award-winning educational website aimed primarily at medical students and radiology residents-in-training, containing lectures, handouts, images, Cases of the Week, archives of cases, quizzes, flashcards of differential diagnoses and “most commons” lists, primarily in the areas of chest, GI, GU cardiac, bone and neuroradiology. |
