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Case of the Week 365




What's the most likely diagnosis?

  • 49 year-old with bilateral arm pain



AP views of both upper extremities

  1. Shoulder dislocations
  2. Thalidomide-induced phocomelia
  3. Holt-Oram Syndrome
  4. Fibrous dysplasia
  5. Radiation osteitis

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Answer:

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2. Thalidomide-induced phocomelia

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More (Click Discussion Tab)


Thalidomide-induced Phocomelia

General Considerations

  • From about 1957-1961, Thalidomide found use in Europe, Japan, Australia and Canada as an anti-emetic during pregnancy until it was found to be a teratogen causing birth defects
  • It is estimated that 10,000 babies were born with defects before the drug was banned worldwide
    • It is also estimated that 40% died of birth defects
  • Fetuses were found to be vulnerable to upper limb phocomelia between days 27-30 of gestation and only a single dose of the drug could produce defects

    More ...


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    LearningRadiology.com
    is an award-winning educational website aimed primarily at medical students and radiology residents-in-training, containing  lectures, handouts, images, Cases of the Week, archives of cases, quizzes, flashcards of differential diagnoses and “most commons” lists, primarily in the areas of chest, GI, GU cardiac, bone and neuroradiology.