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Case of the Week 357

What's the most likely diagnosis?

  • 51 year-old female with dysphagia

Frontal Chest Radiograph

  1. Eosinophilic granuloma
  2. Tuberculosis
  3. Alveolar sarcoid
  4. Loeffler's Syndrome
  5. Scleroderma

Additional Image - Axial CT image of the lower chest


Additional Image


Axial CT image of the lower chest




5. Scleroderma



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General Considerations

  • Multisystem collagen vascular connective tissue disease mediated by a vasculitis
  • Unknown etiology
  • Most common form 30-50
  • Female to male ratio of 3:1
  • Pulmonary manifestations in 10-25% of patients with scleroderma, but…
  • Lungs are involved in almost 100% of cases at autopsy


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