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Case of the Week 333

What's the most likely diagnosis?

  • 68 year-old female with headaches

  1. Fibrous dysplasia
  2. Paget disease
  3. Hyperostosis frontalis interna
  4. Metastases
  5. Multiple myeloma

Additional Images - Axial CT image of skull


Additional Images

Axial CT image of skull


3. Hyperostosis frontalis interna

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Hyperostosis Frontalis Interna

General Considerations

  • Occurs mostly in post-menopausal females over 35 years of age
  • Thickening of the inner table of the skull
  • Unknown etiology although its presence in post-menopausal women suggest possible hormonal influence


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