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Case of the Week 323

What's the most likely diagnosis?

  • 10 year-old with abnormal skull radiograph

  1. Neuroblastoma
  2. Lytic phase of Paget disease
  3. Leptomeningeal cyst
  4. Metastatic prostate carcinoma
  5. Eosinophilic granuloma

Additional Images - Axial CT scan of the skull


Additional Images

Axial CT of the brain displayed with bone window


5. Eosinophilic granuloma

More (Click Discussion Tab)

Eosinophilic Granuloma of the Skull

General Considerations

  • Also known as eosinophilic granuloma(tosis)
  • Proliferative disorder of the Langerhans cells
    • Normally found in the skin (and a few other organs) and serve as antigen-presenting cells
  • Rare diseases, affecting neonates up to adults
  • 2:1 male to female predominance
  • Prognosis
    • Mortality and morbidity are associated with the clinical presentation and age of onset of the disease
    • Worst prognosis for neonates presenting with the disseminated form

More ...

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