What's the most likely diagnosis?
- 10 year-old with abnormal skull radiograph
- Neuroblastoma
- Lytic phase of Paget disease
- Leptomeningeal cyst
- Metastatic prostate carcinoma
- Eosinophilic granuloma
Additional Images - Axial CT scan of the skull
Additional Images
Axial CT of the brain displayed with bone window
Answer:
5. Eosinophilic granuloma
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Eosinophilic Granuloma of the Skull
General Considerations
- Also known as eosinophilic granuloma(tosis)
- Proliferative disorder of the Langerhans cells
- Normally found in the skin (and a few other organs) and serve as antigen-presenting cells
- Rare diseases, affecting neonates up to adults
- 2:1 male to female predominance
- Prognosis
- Mortality and morbidity are associated with the clinical presentation and age of onset of the disease
- Worst prognosis for neonates presenting with the disseminated form
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