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Case of the Week 247

What's the most likely diagnosis?

  • 72 year-old with shortness of breath

  1. Calcification of the Aortic Valve
  2. Tuberculosis
  3. Pericardial Calcification
  4. Calcification of the Mitral Annulus
  5. Calcification of the Mitral Leaflets



4. Calcification
of the Mitral Annulus



More (Click Discussion Tab)

Calcification of the Mitral Annulus

Mitral annulus frequently calcifies over the age of 60

  • One of the most common cardiac calcifications
  • Has been considered to be a degenerative process
  • Calcification is actually subvalvular in location
  • Associations
    • Aortic stenosis
    • Hypertrophic cardiomyopathy
    • Chronic renal failure, especially of those on dialysis
    • Bacterial endocarditis
    • Systemic hypertension
    • Diabetes mellitus
    • Hypercholesterolemia
  • It may be associated with significant atherosclerosis
  • In one study, it was found to be associated with twice the risk of stroke, independent of other risk factors
  • In another study, it was associated with an increased prevalence of coronary artery disease in patients <65

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