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Calcinosis Universalis


  • Diffuse cutaneous, subcutaneous and sometimes muscular calcification

  • Usually affects children and young adults

  • Not actual bone formation

  • More linear than calcifications in scleroderma (calcinosis circumscripta)

  • Seen with dermatomyositis (polymyositis)

    • Dermatomyositis

      • Damaged chondroitin sulfate, atrophy of muscles, followed by calcification of muscle and subcu tissue

      • Ages 5-10 and again in 50s

        • More common in females

      • Linear and confluent calcifications in soft tissues of extremities

      • Acro-osteolysis

      • Chest-may have infiltrates associated

    • Clinically

      • Weakness of respiratory muscles

      • Erythematous rash of eyelids

      • Proximal muscle weakness

      • Associated with a high incidence of malignancies of GI tract, lung, ovary , breast, kidney

  • May resemble myositis ossificans progressiva

    • Myositis ossificans progressive (fibrodyplasia ossificans progressiva)

      • Begins with subcutaneous, painful masses in neck

        • Progresses down back over shoulders, chest, abdomen

      • Rounded or linear calcification starting in neck

      • More clumplike in places than  calcinosis universalis

      • Ossification of voluntary muscles



Calcinosis universalis

Dermatomyositis. Sheet-like calcifications seen in patients with
dermatomyositis is called calcinosis universalis because of its wide-spread distribution.
This is more likely to occur in younger patients with dermatomyositis.

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