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Calcinosis Universalis
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Diffuse cutaneous, subcutaneous and
sometimes muscular calcification
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Usually affects children and young adults
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Not actual bone formation
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More linear than calcifications in
scleroderma (calcinosis circumscripta)
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Seen with dermatomyositis (polymyositis)
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Dermatomyositis
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Damaged chondroitin sulfate, atrophy
of muscles, followed by calcification of muscle and subcu tissue
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Ages 5-10 and again in 50s
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Linear and confluent calcifications
in soft tissues of extremities
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Acro-osteolysis
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Chest-may have infiltrates associated
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Clinically
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Weakness of respiratory muscles
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Erythematous rash of eyelids
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Proximal muscle weakness
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Associated with a high incidence of
malignancies of GI tract, lung, ovary , breast, kidney
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May resemble myositis ossificans
progressiva
Dermatomyositis. Sheet-like calcifications seen in patients with
dermatomyositis is called calcinosis universalis because of its wide-spread distribution.
This is more likely to occur in younger patients with dermatomyositis.
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